Store-operated calcium (Ca2+) entry (SOCE) occurs through a widely distributed family of
ion channels activated by the loss of Ca2+ from the endoplasmic reticulum (ER). The best …

Stromal interaction molecules (STIM) are a distinct class of ubiquitously expressed single-
pass transmembrane proteins in the endoplasmic reticulum (ER) membrane. Together with …

Depletion of Ca 2+ from the endoplasmic reticulum (ER) causes the ER Ca 2+ sensor STIM1
to form membrane contact sites (MCSs) with the plasma membrane (PM). At the ER-PM …

STIM1 and STIM2 are endoplasmic reticulum (ER) membrane proteins that sense decreases
in ER-luminal free Ca 2+ and, through a conformational change in the STIM cytoplasmic …

Abstract Stromal interaction molecule 1 (STIM1) monitors ER-luminal Ca2+ levels to
maintain cellular Ca2+ balance and to support Ca2+ signalling. The prevailing view has …

Asthma is one of the main non-communicable chronic diseases and affects a huge portion of
the population. It is a multifactorial disease, classified into several phenotypes, being the …

Substantial progress has been made in the past several years in establishing the
stoichiometries of STIM and Orai proteins and understanding their influence on store …

STIM1 and Orai1 are key components of the Ca2+-release activated Ca2+ (CRAC) current.
Orai1, which represents the subunit forming the CRAC channel complex, is activated by the …

Store-operated calcium entry (SOCE) through Orai ion channels is an intracellular signaling
pathway that is initiated by ligand-induced depletion of calcium from the endoplasmic …

Pulmonary arterial hypertension (PAH) is a severe and multifactorial disease. PAH
pathogenesis mostly involves pulmonary arterial endothelial and pulmonary arterial smooth …