The role of IgLON cell adhesion molecules in neurodegenerative diseases

M Salluzzo, C Vianello, S Abdullatef, R Rimondini… - Genes, 2023 - mdpi.com
In the brain, cell adhesion molecules (CAMs) are critical for neurite outgrowth, axonal
fasciculation, neuronal survival and migration, and synapse formation and maintenance …

How “Neuronal” are human skin mast cells?

M Babina, K Franke, G Bal - International Journal of Molecular Sciences, 2022 - mdpi.com
Mast cells are evolutionarily old cells and the principal effectors in allergic responses and
inflammation. They are seeded from the yolk sac during embryogenesis or are derived from …

Spatiotemporal dynamics of the molecular expression pattern and intercellular interactions in the glial scar response to spinal cord injury

L Gong, Y Gu, X Han, C Luan, C Liu, X Wang… - Neuroscience …, 2023 - Springer
Nerve regeneration in adult mammalian spinal cord is poor because of the lack of intrinsic
regeneration of neurons and extrinsic factors–the glial scar is triggered by injury and inhibits …

NEGR1 and FGFR2 cooperatively regulate cortical development and core behaviours related to autism disorders in mice

J Szczurkowska, F Pischedda, B Pinto, F Manago… - Brain, 2018 - academic.oup.com
Autism spectrum disorders are neurodevelopmental conditions with diverse aetiologies, all
characterized by common core symptoms such as impaired social skills and communication …

Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders

K Singh, M Jayaram, M Kaare, E Leidmaa… - Scientific reports, 2019 - nature.com
Abstract Neuronal growth regulator 1 (NEGR1) belongs to the immunoglobulin (IgLON)
superfamily of cell adhesion molecules involved in cortical layering. Recent functional and …

Dpr10 and Nocte are required for Drosophila motor axon pathfinding

M Lobb-Rabe, K DeLong, RJ Salazar, R Zhang… - Neural …, 2022 - Springer
The paths axons travel to reach their targets and the subsequent synaptic connections they
form are highly stereotyped. How cell surface proteins (CSPs) mediate these processes is …

Histone variant macroH2A1. 1 enhances nonhomologous end joining-dependent DNA double-strand-break repair and reprogramming efficiency of human iPSCs

S Giallongo, D Řeháková, T Biagini, O Lo Re… - Stem Cells, 2022 - academic.oup.com
DNA damage repair (DDR) is a safeguard for genome integrity maintenance. Increasing
DDR efficiency could increase the yield of induced pluripotent stem cells (iPSC) upon …

Using high-density SNP data to unravel the origin of the Franches-Montagnes horse breed

AI Gmel, S Mikko, A Ricard, BD Velie, V Gerber… - Genetics Selection …, 2024 - Springer
Abstract Background The Franches-Montagnes (FM) is the last native horse breed of
Switzerland, established at the end of the 19th century by cross-breeding local mares with …

Highly conserved molecular features in IgLONs contrast their distinct structural and biological outcomes

H Venkannagari, JM Kasper, A Misra, SA Rush… - Journal of molecular …, 2020 - Elsevier
Abstract Neuronal growth regulator 1 (NEGR1) and neurotrimin (NTM) are abundant cell-
surface proteins found in the brain and form part of the IgLON (Immunoglobulin LSAMP …

Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome‐Wide Interaction Meta‐Analysis in the International Consortium for Antihypertensive …

CW McDonough, HR Warren, JR Jack… - Clinical …, 2021 - Wiley Online Library
We sought to identify genome‐wide variants influencing antihypertensive drug response
and adverse cardiovascular outcomes, utilizing data from four randomized controlled trials in …