The M1/M2 macrophage paradigm plays a key role in tumor progression. M1 macrophages
are historically regarded as anti-tumor, while M2-polarized macrophages, commonly …

The novel coronavirus SARS-CoV2 causes COVID-19, a pandemic threatening millions. As
protective immunity does not exist in humans and the virus is capable of escaping innate …

The immunosuppressive tumor microenvironment (TME) represents a major barrier for
effective immunotherapy. Tumor-associated macrophages (TAMs) are highly heterogeneous …

Deficits in neuronal function are a hallmark of spinal cord injury (SCI) and therapeutic efforts
are often focused on central nervous system (CNS) axon regeneration. However, secondary …

Solid tumors elicit a detectable immune response including the infiltration of tumor-
associated macrophages (TAMs). Unfortunately, this immune response is co-opted into …

Innate immune responses, particularly activation of macrophages and microglia, are
increasingly implicated in CNS disorders. It is now appreciated that the heterogeneity of …

Macrophages are among the most common cells in the colorectal cancer microenvironment,
but their prognostic significance is incompletely understood. Using multiplexed …

Cancer progression is primarily caused by interactions between transformed cells and the
components of the tumor microenvironment (TME). TAMs (tumor-associated macrophages) …

The emergence of the new COVID-19 virus is proving to be a challenge in seeking effective
therapies. Since the most severe clinical manifestation of COVID-19 appears to be a severe …

Macrophages are critical mediators of the innate immune response against foreign
pathogens, including bacteria, physical stress, and injury. Therefore, these cells play a key …