This review focuses on mechanisms and emerging concepts that drive the science of stroke
in a therapeutic direction. Once considered exclusively a disorder of blood vessels, growing …

Intrapartum-related events are the third leading cause of childhood mortality worldwide and
result in one million neurodisabled survivors each year. Infants exposed to a perinatal insult …

Hypoxia is a distinct feature of malignant solid tumors, which is a possible causative factor
for the serious resistance to chemo-and radiotherapy or the development of invasion and …

Sublethal hypoxic or ischemic events can improve the tolerance of tissues, organs, and even
organisms from subsequent lethal injury caused by hypoxia or ischemia. This phenomenon …

Neuroprotection and brain repair in patients after acute brain damage are still major
unfulfilled medical needs. Pharmacological treatments are either ineffective or confounded …

Adaptation is one of physiology's fundamental tenets, operating not only at the level of
species, as Darwin proposed, but also at the level of tissues, cells, molecules and, perhaps …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

1. Stroke is the neurological evidence of a critical reduction of cerebral blood flow in a
circumscribed part of the brain, resulting from the sudden or gradually progressing …

Glutamate excitotoxicity, oxidative stress, and acidosis are primary mediators of neuronal
death during ischemia and reperfusion. Astrocytes influence these processes in several …

The transcription factor NF-κB is a key regulator of hundreds of genes involved in cell
survival and inflammation. There is ample evidence that NF-κB is activated in cerebral …