Neutrophils are the most abundant leukocytes in blood. From the circulation, they are quickly
mobilized to sites of inflammation and/or infection. At the affected tissues, neutrophils display …

Neutrophils are main players in the effector phase of the host defense against micro-
organisms and have a major role in the innate immune response. Neutrophils show …

Intron retention (IR) is widely recognized as a consequence of mis-splicing that leads to
failed excision of intronic sequences from pre-messenger RNAs. Our bioinformatic analyses …

Polymorphonuclear leukocytes (PMNs) are the most abundant white cell in humans and an
essential component of the innate immune system. PMNs are typically the first type of …

During acute infectious and inflammatory conditions, a large number of neutrophils are in
high demand as they are consumed in peripheral organs. The hematopoietic system rapidly …

Purpose To assess the prognostic relevance of mutations in the CEBPA gene encoding
CCAAT/enhancer binding protein alpha (C/EBPα) in a large prospective series of younger …

Following its highly successful and well-respected first edition, this thoroughly revised
edition offers much more! Edited and authored by leading authorities in hematology, this …

Neutrophils are vital for the innate immune system's control of pathogens and neutrophil
deficiency can render the host susceptible to life-threatening infections. Neutrophil …

The relevance of molecular mechanisms governing mitochondrial proteostasis to the
differentiation and function of hematopoietic and immune cells is largely elusive. Through …

Granulocytes and monocytes develop from a common myeloid progenitor. Early
granulopoiesis requires the C/EBPα, PU. 1, RAR, CBF, and c-Myb transcription factors, and …