Developing novel targeted anticancer therapies is a major goal of current research. The use
of poly (ADP-ribose) polymerase (PARP) inhibitors in patients with homologous …

The patients with high microsatellite instability (MSI-H)/mismatch repair deficient (dMMR)
tumors recently have been reported that can benefit from immunotherapy, and MSI can be …

We conducted the Reproducibility Project: Cancer Biology to investigate the replicability of
preclinical research in cancer biology. The initial aim of the project was to repeat 193 …

Breast cancer is a common cancer affecting a large number of patients. Notably, 5–10% of
all breast cancer patients are genetically predisposed to cancers. Although the most …

Constitutive heterochromatin is a major component of the eukaryotic nucleus and is
essential for the maintenance of genome stability. Highly concentrated at pericentromeric …

The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA
double-strand break (DSB) repair by homologous recombination and protects DNA …

Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …

Recent efforts have succeeded in surveying open chromatin at the single-cell level, but high-
throughput, single-cell assessment of heterochromatin and its underlying genomic …

Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …

Satellite DNA represents one of the most fascinating parts of the repetitive fraction of the
eukaryotic genome. Since the discovery of highly repetitive tandem DNA in the 1960s, a lot …