As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

The ability of cells to respond to mechanical forces is critical for numerous biological
processes. Emerging evidence indicates that external mechanical forces trigger changes in …

INTRODUCTION The chromosome breakage-fusion-bridge (BFB) cycle is a catastrophic
mutational process, common during tumorigenesis, that results in gene amplification and …

Quantitative phase imaging has gained popularity in bioimaging because it can avoid the
need for cell staining, which, in some cases, is difficult or impossible. However, as a result …

Aberrant chromosomal architecture, ranging from small insertions or deletions to large
chromosomal alterations, is one of the most common characteristics of cancer genomes …

The physical characteristics of tumours are intricately linked to the tumour phenotype and
difficulties during treatment. Many factors contribute to the increased stiffness of tumours; …

Whether cell forces or extracellular matrix (ECM) can impact genome integrity is largely
unclear. Here, acute perturbations (∼ 1 h) to actomyosin stress or ECM elasticity cause …

Metastasis involves dissemination of cancer cells away from a primary tumour and
colonization at distal sites. During this process, the mechanical properties of the nucleus …

The nucleus is physically linked to the cytoskeleton, adhesions, and extracellular matrix—all
of which sustain forces, but their relationships to DNA damage are obscure. We show that …

The nuclear envelope is often depicted as a static barrier that regulates access between the
nucleus and the cytosol. However, recent research has identified many conditions in …