The diagnosis of brain metastasis (BrM) has historically been a dooming diagnosis that is
nothing less than a death sentence, with few treatment options for palliation or prolonging …

Context Stereotactic ablative body radiotherapy (SABR) is an emerging treatment modality
for primary and metastatic renal cell carcinoma (RCC). Objective To review and summarise …

Brain metastases are a challenging manifestation of renal cell carcinoma. We have a limited
understanding of brain metastasis tumor and immune biology, drivers of resistance to …

Background Intracranial activity of lapatinib has been demonstrated in several studies in
patients with human epidermal growth factor receptor-2 positive breast cancers (HER-2+ …

Highlights•This article provides ESMO expert recommendations adapted for the treatment of
renal cell carcinomas in Asian patients.•The aim was to provide guidance for the …

Stereotactic radiosurgery (SRS) is a standard option for brain metastases (BM). There is lack
of consensus when patients have a systemic treatment, if a washout is necessary. The aim of …

Objectives To evaluate the safety and efficacy of stereotactic radiotherapy (SRT) in patients
with metastatic renal cell carcinoma (mRCC) concurrently receiving targeted therapy (TT) or …

Simple Summary Brain metastases are a commonly recognized poor prognostic factor in
patients with cancer. Due to their poor prognosis, these patients were commonly excluded …

Background: Targeted therapy has transformed the outcome for patients with metastatic
renal cell carcinoma. Their efficacy and safety have also been demonstrated in brain …

Background There is a paucity of data on the safety of cabozantinib use in combination with
radiotherapy. Objective To report the practice patterns, safety, and efficacy of cabozantinib …