The lung is an attractive target for drug delivery due to noninvasive administration via
inhalation aerosols, avoidance of first-pass metabolism, direct delivery to the site of action …

Spleen tyrosine kinase (Syk) is a cytoplasmic protein tyrosine kinase well known for its
ability to couple immune cell receptors to intracellular signaling pathways that regulate …

Recent advances in the knowledge of asthma pathobiology suggest that biological therapies
that target cytokines can be potentially useful for the treatment of this complex and …

Antigen-mediated aggregation of IgE bound to its high-affinity receptor on mast cells or
basophils initiates a complex series of biochemical events, resulting in the release of …

Current therapy for asthma with inhaled corticosteroids and long-acting inhaled β 2-agonists
is highly effective, safe and relatively inexpensive, but for many patients, their disease …

Effective treatment of severe asthma is a major unmet need because patients' symptoms are
not controlled on maximum treatment with inhaled therapy. Asthma symptoms can be poorly …

Multiple kinases play a critical role in orchestrating the chronic inflammation and structural
changes in the respiratory tract of patients with asthma and chronic obstructive pulmonary …

Asthma is a major and increasing global health problem and, despite major advances in
therapy, many patients' symptoms are not adequately controlled. Treatment with …

The STAT3 transcription factor is critical for cytokine signaling and the acute phase
response, but its role in allergic asthma is largely undefined. To investigate the role of …

Recent advances in our understanding of allergic and autoimmune disorders have begun to
translate into novel, effective and safe medicines for these common maladies. Examples …