NAFLD is closely linked with hepatic insulin resistance. Accumulation of hepatic
diacylglycerol activates PKC-ε, impairing insulin receptor activation and insulin-stimulated …

Obesity is an important aspect of the metabolic syndrome and is often associated with
chronic inflammation. In this context, inflammation of organs participating in energy …

Adipose tissue, best known for its role in fat storage, can also suppress weight gain and
metabolic disease through the action of specialized, heat-producing adipocytes. Brown …

The hepatic accumulation of excess triglycerides is a seminal event in the initiation and
progression of non-alcoholic fatty liver disease (NAFLD). Hepatic steatosis occurs when the …

In mammals, excess energy is stored primarily as triglycerides, which are mobilized when
energy demands arise. This review mainly focuses on the role of long chain fatty acids …

Igniting thermogenesis within white adipose tissue (ie, promoting expression and activity of
the uncoupling protein UCP1) has attracted much interest. Numerous" browning agents" …

Imbalances in glucose and energy homeostasis are at the core of the worldwide epidemic of
obesity and diabetes. Here, we illustrate an important role of the TGF-β/Smad3 signaling …

Alterations in nonshivering thermogenesis are presently discussed as being both potentially
causative of and able to counteract obesity. However, the necessity for mammals to defend …

Bile acids (BAs) play a crucial role in nutrient absorption and act as key regulators of lipid
and glucose metabolism and immune homeostasis. Through the enterohepatic circulation …

In mammalian cells, elongases and desaturases play critical roles in regulating the length
and degree of unsaturation of fatty acids and thereby their functions and metabolic fates. In …