Stand up to stand out: natural dietary polyphenols curcumin, resveratrol, and gossypol as potential therapeutic candidates against severe acute respiratory syndrome …

Z Wang, X Song, W Xu, S Lei, H Zhang, L Yang - Nutrients, 2023 - mdpi.com
The COVID-19 pandemic has stimulated collaborative drug discovery efforts in academia
and the industry with the aim of developing therapies and vaccines that target SARS-CoV-2 …

[HTML][HTML] Immunomodulatory and chemopreventive effects of resveratrol on the digestive system cancers

M Djaldetti - Oncology Research, 2024 - pmc.ncbi.nlm.nih.gov
Resveratrol (RSV), the primary polyphenol found in grapes, has been revealed to have anti-
inflammatory properties by reducing the capacity of the peripheral blood mononuclear cells …

Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural …

LR Padgett, MR Shinkle, S Rosario, TM Stewart… - Human Genetics and …, 2023 - cell.com
DHPS deficiency is a rare genetic disease caused by biallelic hypomorphic variants in the
Deoxyhypusine synthase (DHPS) gene. The DHPS enzyme functions in mRNA translation …

Multifaceted impact of HIV inhibitor dapivirine on triple negative breast cancer cells reveals potential entities as targets for novel therapy

K Patil, E Johnston, J Novack, G Wallace, M Lin… - Scientific Reports, 2024 - nature.com
Breast cancer is the most common cancer in women worldwide. Many breast cancers
originate from the cells lining the milk duct and some become invasive. Breast cancer …

Multifaceted Effects of Kinase Inhibitors on Pancreatic Cancer Cells Reveals Pivotal Entities with Therapeutic Implications

YN Kim, K Patil, J Ma, GA Dufek, SB Pai - Biomedicines, 2023 - mdpi.com
Pancreatic cancer is one of the most aggressive forms of cancer and is the seventh leading
cause of cancer deaths worldwide. Pancreatic ductal adenocarcinoma (PDAC) accounts for …

Casticin impacts key signaling pathways in colorectal cancer cells leading to cell death with therapeutic implications

M Kowalski, A Assa, K Patil, C Terrell, N Holliday… - Genes, 2022 - mdpi.com
Colorectal cancer is the third most frequently encountered cancer worldwide. While current
chemotherapeutics help to manage the disease to some extent, they have eluded achieving …

Disruption of Glioblastoma Multiforme Cell Circuits with Cinnamaldehyde Highlights Potential Targets with Implications for Novel Therapeutic Strategies

S Srivastava, K Patil, EW Thompson, SA Nakhai… - Cells, 2023 - mdpi.com
Glioblastoma multiforme (GBM) is a major aggressive primary brain tumor with dismal
survival outcome and few therapeutic options. Although Temozolomide (TMZ) is a part of the …

[PDF][PDF] Análisis del efecto del resveratrol como quimiosensibilizador en líneas celulares de cáncer cervicouterino a través de la inhibición de la vía de reparación …

A Hernández, A Marina - 2023 - repositorio.cinvestav.mx
El cáncer cervicouterino es uno de los de los cánceres con mayor incidencia y letalidad en
todo el mundo, sobre todo en países en vías de desarrollo como México. El cisplatino es …

Disruption of Colorectal cancer network by polyphyllins reveals pivotal entities with implications for chemoimmunotherapy

R Siripuram, Z Bartolek, K Patil, SS Gill, SB Pai - Biomedicines, 2022 - mdpi.com
The prevalence of colorectal cancer has increased world-wide with high rates of mortality
and morbidity. In the absence of efficacious drugs to treat this neoplasia, there is an …

[PDF][PDF] WIP: A novel problem-driven learning laboratory course in which biomedical engineering students conduct experiments of their own design to answer an …

B Pai, K Patil, T Fernandez, P Benkeser… - 2022 ASEE Annual …, 2022 - peer.asee.org
Often, in traditional laboratory courses, students carry out “experiments” for which the results
are already known, following protocols that they are expected to perform as written. Using …