Neurodegenerative disorders represent a major and growing healthcare challenge globally.
Among the numerous molecular pathways implicated in their pathogenesis, calpain …

Rationale: Glycolytic shift is implicated in the pathogenesis of pulmonary arterial
hypertension (PAH). It remains unknown how glycolysis is increased and how increased …

The intercalated disk is a cardiac specific structure composed of three main protein
complexes—adherens junctions, desmosomes, and gap junctions—that work in concert to …

Cancer stem cells (CSCs) are the most important cause of cancer treatment failure.
Traditional cancer treatments, such as chemotherapy and radiotherapy, damage healthy …

Calpain mediates collagen synthesis and cell proliferation and plays an important role in
pulmonary vascular remodeling in pulmonary arterial hypertension (PAH). In the present …

The induction of acute endoplasmic reticulum (ER) stress damages the electron transport
chain (ETC) in cardiac mitochondria. Activation of mitochondria‐localized calpain 1 (CPN1) …

Calpain is a family of calcium-dependent nonlysosomal neutral cysteine endopeptidases.
Akt is a serine/threonine kinase that belongs to AGC kinases and plays important roles in …

Triple‐negative breast cancer (TNBC) is an aggressive type of breast cancer in which
calpain system plays an important role in its cellular processes including apoptosis and …

Several studies have demonstrated that calpain‑1 is involved in a variety of
pathophysiological processes, including tumorigenesis. However, the clinical relevance and …

In the last years, an increasing number of studies reported that food pollution represents a
significant route of exposure to environmental toxicants, able to cause mild to severe food …