Differential roles of hypothalamic AVPV and arcuate kisspeptin neurons in estradiol feedback regulation of female reproduction

L Wang, SM Moenter - Neuroendocrinology, 2020 - karger.com
Mammalian reproductive function includes puberty onset and completion, reproductive
cyclicity, steroidogenesis, gametogenesis, fertilization, pregnancy, and lactation; all are …

Hypothalamic kisspeptin neurons as potential mediators of estradiol negative and positive feedback

JR Starrett, SM Moenter - Peptides, 2023 - Elsevier
Gonadal steroid feedback regulates the brain's patterned secretion of gonadotropin-
releasing hormone (GnRH). Negative feedback, which occurs in males and during the …

AgRP to Kiss1 neuron signaling links nutritional state and fertility

SL Padilla, J Qiu, CC Nestor, C Zhang… - Proceedings of the …, 2017 - National Acad Sciences
Mammalian reproductive function depends upon a neuroendocrine circuit that evokes the
pulsatile release of gonadotropin hormones (luteinizing hormone and follicle-stimulating …

High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons

J Qiu, CC Nestor, C Zhang, SL Padilla, RD Palmiter… - Elife, 2016 - elifesciences.org
Kisspeptin (Kiss1) and neurokinin B (NKB) neurocircuits are essential for pubertal
development and fertility. Kisspeptin neurons in the hypothalamic arcuate nucleus …

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

N Barban, R Jansen, R De Vlaming, A Vaez… - Nature …, 2016 - nature.com
The genetic architecture of human reproductive behavior—age at first birth (AFB) and
number of children ever born (NEB)—has a strong relationship with fitness, human …

Positive, but not negative feedback actions of estradiol in adult female mice require estrogen receptor α in kisspeptin neurons

SL Dubois, M Acosta-Martínez, MR DeJoseph… - …, 2015 - academic.oup.com
Hypothalamic kisspeptin (Kiss1) neurons express estrogen receptor α (ERα) and exert
control over GnRH/LH secretion in female rodents. It has been proposed that estradiol (E2) …

Estrogenic-dependent glutamatergic neurotransmission from kisspeptin neurons governs feeding circuits in females

J Qiu, HM Rivera, MA Bosch, SL Padilla, TL Stincic… - Elife, 2018 - elifesciences.org
The neuropeptides tachykinin2 (Tac2) and kisspeptin (Kiss1) in hypothalamic arcuate
nucleus Kiss1 (Kiss1ARH) neurons are essential for pulsatile release of GnRH and …

Optogenetic stimulation of arcuate nucleus Kiss1 neurons reveals a steroid-dependent glutamatergic input to POMC and AgRP neurons in male mice

CC Nestor, J Qiu, SL Padilla, C Zhang… - Molecular …, 2016 - academic.oup.com
Kisspeptin (Kiss1) neurons are essential for reproduction, but their role in the control of
energy balance and other homeostatic functions remains unclear. Proopiomelanocortin …

Genetic dissection of the different roles of hypothalamic kisspeptin neurons in regulating female reproduction

L Wang, C Vanacker, LL Burger, T Barnes, YM Shah… - Elife, 2019 - elifesciences.org
The brain regulates fertility through gonadotropin-releasing hormone (GnRH) neurons.
Estradiol induces negative feedback on pulsatile GnRH/luteinizing hormone (LH) release …

Glutamatergic transmission to hypothalamic kisspeptin neurons is differentially regulated by estradiol through estrogen receptor α in adult female mice

L Wang, LL Burger, ML Greenwald-Yarnell… - Journal of …, 2018 - Soc Neuroscience
Estradiol feedback regulates gonadotropin-releasing hormone (GnRH) neurons and
subsequent luteinizing hormone (LH) release. Estradiol acts via estrogen receptor α (ERα) …