Triple-negative breast cancer (TNBC) is a subtype of human breast cancer with one of the
worst prognoses, with no targeted therapeutic strategies currently available. Regulated cell …

Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural
spirooxindole-containing compounds have been identified as bio-promising agents …

Small-molecule kinase inhibitors are being continuously explored as new anticancer
therapeutics. Kinases are the phosphorylating enzymes which regulate numerous cellular …

The hydrophobic and the hydrophilic rims in the active site of human carbonic anhydrase IX
(hCA IX) which as well contains a zinc ion as part of the catalytic core, were simultaneously …

Spirocompounds constitute an important class of organic frameworks enveloping numerous
pharmacological activities, among them, the promising anticancer potential of …

Changes in gene expression cause uncontrolled cell proliferation and consequently tumor
hypoxia. The tumor cells shift their metabolism to anaerobic glycolysis with a significant …

In recent years, spiro compounds have attracted significant interest in medicinal chemistry
due to their numerous biological activities attributed primarily to their versatility and structural …

DES are mixtures of two or more compounds, able to form liquids upon mixing, with lower
freezing points when compared to the individual constituents (eutectic mixtures). This …

Herein, we report the synthesis of different novel sets of coumarin-6-sulfonamide derivatives
bearing different functionalities (4a, b, 8a–d, 11a–d, 13a, b, and 15a–c), and in vitro …

Herein we report the design and synthesis of novel N-substituted isatins-SLC-0111 hybrids
(6a-f and 9a-l). A structural extension approach was adopted via N-alkylation and N …