Alkaline phosphatase (ALP) is highly expressed in the cells of mineralized tissue and plays
a critical function in the formation of hard tissue. The existing status of this critical enzyme …

Biomineralization is the process by which hydroxyapatite is deposited in the extracellular
matrix. Physiological mineralization occurs in hard tissues, whereas pathological …

Our knowledge of the structure and function of alkaline phosphatases has increased greatly
in recent years. The crystal structure of the human placental isozyme has enabled us to …

Abstract Background Matrix vesicles (MVs) are released from hypertrophic chondrocytes
and from mature osteoblasts, the cells responsible for endochondral and membranous …

Hypophosphatasia is a rare inherited disorder characterized by defective bone and tooth
mineralization, and deficiency of serum and bone alkaline phosphatase activity. The …

A review and discussion of new knowledge on the structure and function of mammalian
alkaline phosphatases (APs) gained over the last 25 years. It covers:* The structure …

Introduction: Hypophosphatasia (HPP) is the inborn error of metabolism that features rickets
or osteomalacia caused by loss‐of‐function mutation (s) within the gene that encodes the …

We report three novel inhibitors of the physiological pyrophosphatase activity of alkaline
phosphatase and show that these compounds are capable of reducing calcification in two …

We review here clinical, pathophysiological, diagnostic, genetic and molecular aspects of
Hypophosphatasia (HPP), a rare inherited metabolic disorder. The clinical presentation is a …

During the process of endochondral bone formation, chondrocytes and osteoblasts
mineralize their extracellular matrix by promoting the formation of hydroxyapatite seed …