Risk for Alzheimer's disease (AD) is associated with age-related loss of sex steroid
hormones in both women and men. In post-menopausal women, the precipitous depletion of …

Cardiovascular disease (CVD) is the number one cause of morbidity and mortality in men
and women worldwide. According to the WHO, by 2015, almost 20 million people will die …

Epidermal growth factor receptor (EGFR) signaling plays a substantial role in learning and
memory. The upregulation of EGFR has been embroiled in the pathophysiology of …

Abstract 17β-Hydroxysteroid dehydrogenase type 10 (17β-HSD10) is encoded by the
HSD17B10 gene mapping at Xp11. 2. This homotetrameric mitochondrial multifunctional …

Menopause, a risk factor for brain dysfunction in women, is characterized by
neuropsychological symptoms including depression and dementia, which are closely …

Severe brain metabolic dysfunction and amyloid-β accumulation are key hallmarks of
Alzheimer's disease (AD). While astrocytes contribute to both pathologic mechanisms, the …

Although Alzheimer's disease (AD) characterized with senile plaques and neurofibrillary
tangles has been found for over 100 years, its molecular mechanisms are ambiguous. More …

We have recently found that the combination of ovariectomy (OVX) and chronic restraint
stress (CS) causes hippocampal pyramidal cell loss and cognitive dysfunction in female rats …

Objective This study aims to investigate the effects of early growth response 1 (Egr1) on miR-
106a/signal transducer and activator of transcription 3 (STAT3) regulating cognitive …

Advanced glycation end products (AGEs) have been reported to cause neurodegeneration,
senile plaque formation and spatial learning and memory deficits. There is much evidence …