Three decades of genetic research in Alzheimer disease (AD) have substantially broadened
our understanding of the pathogenetic mechanisms leading to neurodegeneration and …

Neuronal nicotinic receptors (NAChRs) form a heterogeneous family of ion channels that are
differently expressed in many regions of the central nervous system (CNS) and peripheral …

The genetic underpinnings of Alzheimer's disease (AD) remain largely elusive despite early
successes in identifying three genes that cause early-onset familial AD (those that encode …

Neuronal nicotinic acetylcholine receptors comprise a heterogeneous class of cationic
channels that is present throughout the nervous system. These channels are involved both …

Tobacco smoking is an extremely addictive and harmful form of nicotine (NIC) consumption,
but unfortunately also the most prevalent. Although disproportionately high frequencies of …

Desensitization is an intriguing characteristic of ligand-gated channels, whereby a decrease
or loss of biological response occurs following prolonged or repetitive stimulation. Nicotinic …

We tested six single nucleotide polymorphisms (SNPs) in the α4 subunit gene (CHRNA4)
and four SNPs in the β2 subunit gene (CHRNB2) of nicotinic acetylcholine receptors …

With the advent of technologies that allow simultaneous genotyping of thousands of single-
nucleotide polymorphisms (SNPs) across the genome, the genetic contributions to complex …

Alzheimer's disease is a complex and progressive neurodegenerative disease leading to
loss of memory, cognitive impairment, and ultimately death. To date, six large-scale genome …

We elucidated the molecular fingerprint of vulnerable excitatory neurons within select
cortical lamina of individuals with Down syndrome (DS) for mechanistic understanding and …