Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host
responses to infection. Not only does sepsis pose a serious hazard to human health, but it …

Background Inflammation and oxidative damage caused by severe infections may be
attenuated by vitamin C. Methods We conducted a systematic review of randomized …

Background Studies that have evaluated the use of intravenous vitamin C in adults with
sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown …

Inflammation and oxidative stress represent physiological response mechanisms to different
types of stimuli and injury during critical illness. Its proper regulation is fundamental to …

In 1747, an important milestone in the history of clinical research was set, as the Scottish
surgeon James Lind conducted the first randomized controlled trial. Lind was interested in …

The classical model of the vital increase in systemic glucocorticoid availability in response to
sepsis-and hyperinflammation-induced critical illness is one of an activated hypothalamus …

The immune system protects the body from infectious agents such as bacteria, viruses, or
fungi. Once encountered with pathogens or antigens, the innate and adaptive arms of the …

Background To update a meta-analysis of randomized controlled trials (RCTs) and further
explore the outcome of IV vitamin C (IVVC) administration in sepsis or septic shock patients …

Background Previous randomized trials of vitamin C, hydrocortisone, and thiamine on sepsis
were limited by short-term vitamin C administration, heterogeneous populations, and the …

Abstract Background This Rapid Practice Guideline provides an evidence‐based
recommendation to address the question: in adults with sepsis or septic shock, should we …