Chemically engineering cells for precision medicine

Y Wang, Z Li, F Mo, TJ Chen-Mayfield, A Saini… - Chemical Society …, 2023 - pubs.rsc.org
Cell-based therapy holds great potential to address unmet medical needs and revolutionize
the healthcare industry, as demonstrated by several therapeutics such as CAR-T cell …

Human NK cells: From development to effector functions

AS Perera Molligoda Arachchige - Innate immunity, 2021 - journals.sagepub.com
NK cells are the major lymphocyte subset of the innate immune system that mediates
antiviral and anti-tumor responses. It is well established that they develop mechanisms to …

Cell-based drug delivery systems and their in vivo fate

L Yang, Y Yang, Y Chen, Y Xu, J Peng - Advanced Drug Delivery Reviews, 2022 - Elsevier
Cell-based drug delivery systems (DDSs) have received attention recently because of their
unique biological properties and self-powered functions, such as excellent biocompatibility …

Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles

J Qi, F Jin, Y You, Y Du, D Liu, X Xu, J Wang… - Nature …, 2021 - nature.com
Some specific chemotherapeutic drugs are able to enhance tumor immunogenicity and
facilitate antitumor immunity by inducing immunogenic cell death (ICD). However, tumor …

Cell/bacteria‐based bioactive materials for cancer immune modulation and precision therapy

H Pan, M Zheng, A Ma, L Liu, L Cai - Advanced Materials, 2021 - Wiley Online Library
Numerous clinical trials for cancer precision medicine research are limited due to the drug
resistance, side effects, and low efficacy. Unsatisfactory outcomes are often caused by …

Polydopamine–mesoporous silica core–shell nanoparticles for combined photothermal immunotherapy

A Seth, H Gholami Derami, P Gupta… - … applied materials & …, 2020 - ACS Publications
Cancer immunotherapy involves a cascade of events that ultimately leads to cytotoxic
immune cells effectively identifying and destroying cancer cells. Responsive nanomaterials …

Nanoparticle‐laden macrophages for tumor‐tropic drug delivery

W Zhang, M Wang, W Tang, R Wen, S Zhou… - Advanced …, 2018 - Wiley Online Library
Macrophages hold great potential in cancer drug delivery because they can sense
chemotactic cues and home to tumors with high efficiency. However, it remains a challenge …

Immune cell targeting nanoparticles: a review

NK Lee, SN Kim, CG Park - Biomaterials Research, 2021 - spj.science.org
Immune cells are attractive targets for therapy as they are direct participants in a variety of
diseases. Delivering a therapeutic agent only to cells that act on a disease by distinguishing …

Advanced biomaterials for cell‐specific modulation and restore of cancer immunotherapy

S Ruan, Y Huang, M He, H Gao - Advanced Science, 2022 - Wiley Online Library
The past decade has witnessed the explosive development of cancer immunotherapies.
Nevertheless, low immunogenicity, limited specificity, poor delivery efficiency, and off‐target …

Nanoparticles as smart carriers for enhanced cancer immunotherapy

N Thakur, S Thakur, S Chatterjee, J Das… - Frontiers in Chemistry, 2020 - frontiersin.org
Cancer immunotherapy has emerged as a promising strategy for the treatment of many
forms of cancer by stimulating body's own immune system. This therapy not only eradicates …