The failure of animal models to predict therapeutic responses in humans is a major problem
that also brings into question their use for basic research. Organ-on-a-chip (organ chip) …

The pharmaceutical industry has been desperately searching for efficient drug discovery
methods. Organ-on-a-Chip, a cutting-edge technology that can emulate the physiological …

Nucleic acid‐based therapeutics that regulate gene expression have been developed
towards clinical use at a steady pace for several decades, but in recent years the field has …

Abstract Three-dimensional (3D) stem cell culture systems have attracted considerable
attention as a way to better mimic the complex interactions between individual cells and the …

Multiorgan-on-a-chip (multi-OoC) platforms have great potential to redefine the way in which
human health research is conducted. After briefly reviewing the need for comprehensive …

In recent years considerable progress has been made in the development of faithful
procedures for the differentiation of human pluripotent stem cells (hPSCs). An important step …

For the past century, experimental data obtained from animal studies have been required by
reviewers of scientific articles and grant applications to validate the physiological relevance …

Organoids are in vitro self-assembling, organ-like, three-dimensional cellular structures that
stably retain key characteristics of the respective organs. Organoids can be generated from …

The first microfluidic microphysiological systems (MPS) entered the academic scene more
than 15 years ago and were considered an enabling technology to human in vitro (patho) …

Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease
modeling and have unlocked new possibilities for understanding the mechanisms governing …