Pharmacogenetics guidelines: overview and comparison of the DPWG, CPIC, CPNDS, and RNPGx guidelines

H Abdullah-Koolmees, AM Van Keulen… - Frontiers in …, 2021 - frontiersin.org
Many studies have shown that the efficacy and risk of side effects of drug treatment is
influenced by genetic variants. Evidence based guidelines are essential for implementing …

PharmGKB: a worldwide resource for pharmacogenomic information

JM Barbarino, M Whirl‐Carrillo… - … : Systems Biology and …, 2018 - Wiley Online Library
As precision medicine becomes increasingly relevant in healthcare, the field of
pharmacogenomics (PGx) also continues to gain prominence in the clinical setting. Leading …

Pharmacogenetics to guide cardiovascular drug therapy

JD Duarte, LH Cavallari - Nature Reviews Cardiology, 2021 - nature.com
Over the past decade, pharmacogenetic testing has emerged in clinical practice to guide
selected cardiovascular therapies. The most common implementation in practice is …

Moving pharmacogenetics into practice: it's all about the evidence!

JA Luzum, N Petry, AK Taylor… - Clinical …, 2021 - Wiley Online Library
The evidence for pharmacogenetics has grown rapidly in recent decades. However, the
strength of evidence required for the clinical implementation of pharmacogenetics is highly …

Pharmacogenomics in Asians: differences and similarities with other human populations

M Biswas, P Jinda, C Sukasem - Expert Opinion on Drug …, 2023 - Taylor & Francis
ABSTRACT Introduction Various pharmacogenomic (PGx) variants differ widely in different
ethnicities. and clinical outcomes associated with these variants may also be substantially …

Prevalence and risk factors for cisplatin-induced hearing loss in children, adolescents, and young adults: a multi-institutional North American cohort study

DJ Moke, C Luo, J Millstein, KR Knight… - The Lancet Child & …, 2021 - thelancet.com
Background Cisplatin is used to treat a wide range of childhood cancers and cisplatin-
induced hearing loss (CIHL) is a common and debilitating toxicity. We aimed to address …

Pharmacogenomic clinical decision support: a review, how‐to guide, and future vision

DT Wake, DM Smith, S Kazi… - Clinical Pharmacology …, 2022 - Wiley Online Library
Clinical decision support (CDS) is an essential part of any pharmacogenomics (PGx)
implementation. Increasingly, institutions have implemented CDS tools in the clinical setting …

Utility of social media and crowd-intelligence data for pharmacovigilance: a scoping review

AC Tricco, W Zarin, E Lillie, S Jeblee, R Warren… - BMC medical informatics …, 2018 - Springer
Background A scoping review to characterize the literature on the use of conversations in
social media as a potential source of data for detecting adverse events (AEs) related to …

Pharmacogenetics: past, present and future

M Pirmohamed - Drug discovery today, 2011 - Elsevier
The subject area of pharmacogenetics, also known as pharmacogenomics, has a long
history. Research in this area has led to fundamental discoveries, which have helped our …

G protein-coupled receptor (GPCR) pharmacogenomics

MD Thompson, D Reiner-Link, A Berghella… - Critical Reviews in …, 2024 - Taylor & Francis
The field of pharmacogenetics, the investigation of the influence of one or more sequence
variants on drug response phenotypes, is a special case of pharmacogenomics, a discipline …