Increased sensitivity of cancer cells to viruses is a prerequisite for the success of oncolytic
virotherapy. One of the major causes of such a phenotype is the disruption of innate antiviral …

RNA modification is manifested as chemically altered nucleotides, widely exists in diverse
natural RNAs, and is closely related to RNA structure and function. Currently, mRNA-based …

Early biochemical studies of viral replication suggested that most viruses produce double-
stranded RNA (dsRNA), which is essential for the induction of the host immune response …

Paramyxovirus establishes an intimate and complex interaction with the host cell to
counteract the antiviral responses elicited by the cell. Of the various pattern recognition …

The chaperone GRP78/Dna K is conserved throughout evolution down to prokaryotes. The
GRP78 inhibitor OSU‐03012 (AR‐12) interacted with sildenafil (Viagra) or tadalafil (Cialis) …

Newcastle disease (ND) has been a consistent risk factor to the poultry industry worldwide.
Its pathogen, Newcastle disease virus (NDV), is also a promising antitumor treatment …

RIG-I triggers antiviral responses by recognizing viral RNA (vRNA) in the cytoplasm.
However, the spatio-temporal dynamics of vRNA sensing and signal transduction remain …

The arthropod-borne diseases caused by dengue virus (DENV) are a major and emerging
problem of public health worldwide. Infection with DENV causes a series of clinical …

EIF2AK1 and EIF2AK2 encode members of the eukaryotic translation initiation factor 2 alpha
kinase (EIF2AK) family that inhibits protein synthesis in response to physiologic stress …

Introduction Systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and Sjögren's
syndrome (SjS) are inflammatory systemic autoimmune diseases (SADs) that share several …