This chapter is an update of the data on substrates, reactions, inducers, and inhibitors of
human CYP enzymes published previously by Rendic and DiCarlo Citation 1a, Citation 1b …

Covering: up to 2012 Steroids, a widespread class of natural organic compounds occurring
in animals, plants and fungi, have shown great therapeutic value for a broad array of …

The skin, especially the pilosebaceous unit composed of sebaceous glands and hair
follicles, can synthesize androgens de novo from cholesterol or by locally converting …

Benign prostatic hyperplasia (BPH) is the noncancerous proliferation of the prostate gland
associated with benign prostatic obstruction and lower urinary tract symptoms (LUTS) such …

A century after their discovery, phosphonates have become important compounds
recognized both for their use as efficient reagents in organic synthesis and for their …

A novel naphthylmethylimidazole derivative 1 and its related compounds were identified as
17, 20-lyase inhibitors. Based on the structure–activity relationship around the naphthalene …

Aiming at the development of new drugs for the treatment of prostate cancer, the effects of
steroidal compounds and one non-steroidal substance on androgen biosynthesis were …

We report here a molecular modeling investigation of steroidal and nonsteroidal inhibitors of
human cytochrome P450 17α-hydroxylase-17, 20-lyase (CYP17). Using the pharmacophore …

The role of steroidal inhibitors of androgen biosynthesis as potential weapons in the
treatment of prostatic diseases, such as benign prostatic hyperplasia and prostatic cancer …

Conjugation of cholesterol moiety to active compounds for either cancer treatment or
diagnosis is an attractive approach. Cholesterol derivatives are widely studied as cancer …