Cardiac fibrosis

NG Frangogiannis - Cardiovascular research, 2021 - academic.oup.com
Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Transforming growth factor-β in myocardial disease

NG Frangogiannis - Nature Reviews Cardiology, 2022 - nature.com
Transforming growth factor-β (TGFβ) isoforms are upregulated and activated in myocardial
diseases and have an important role in cardiac repair and remodelling, regulating the …

Pericytes in the disease spotlight

H van Splunder, P Villacampa, A Martínez-Romero… - Trends in Cell …, 2024 - cell.com
Pericytes are known as the mural cells in small-caliber vessels that interact closely with the
endothelium. Pericytes play a key role in vasculature formation and homeostasis, and when …

[HTML][HTML] Transforming growth factor–β in tissue fibrosis

NG Frangogiannis - Journal of Experimental Medicine, 2020 - rupress.org
TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially
restricted generation of bioactive TGF-β from latent stores requires the cooperation of …

[HTML][HTML] Spatial multi-omic map of human myocardial infarction

C Kuppe, RO Ramirez Flores, Z Li, S Hayat… - Nature, 2022 - nature.com
Myocardial infarction is a leading cause of death worldwide. Although advances have been
made in acute treatment, an incomplete understanding of remodelling processes has limited …

Inflammatory cytokines and chemokines as therapeutic targets in heart failure

A Hanna, NG Frangogiannis - Cardiovascular Drugs and Therapy, 2020 - Springer
Heart failure exhibits remarkable pathophysiologic heterogeneity. A large body of evidence
suggests that regardless of the underlying etiology, heart failure is associated with induction …

Myofibroblasts and fibrosis: mitochondrial and metabolic control of cellular differentiation

AA Gibb, MP Lazaropoulos, JW Elrod - Circulation research, 2020 - Am Heart Assoc
Cardiac fibrosis is mediated by the activation of resident cardiac fibroblasts, which
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …

Shared and distinct mechanisms of fibrosis

JHW Distler, AH Györfi, M Ramanujam… - Nature Reviews …, 2019 - nature.com
Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …

[HTML][HTML] Platelet-instructed SPP1+ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner

K Hoeft, GJL Schaefer, H Kim, D Schumacher… - Cell Reports, 2023 - cell.com
Fibrosis represents the common end stage of chronic organ injury independent of the initial
insult, destroying tissue architecture and driving organ failure. Here we discover a …

Diffuse myocardial fibrosis: mechanisms, diagnosis and therapeutic approaches

B López, S Ravassa, MU Moreno, GS José… - Nature Reviews …, 2021 - nature.com
Diffuse myocardial fibrosis resulting from the excessive deposition of collagen fibres through
the entire myocardium is encountered in a number of chronic cardiac diseases. This lesion …