Male reproductive disorders and fertility trends: influences of environment and genetic susceptibility

NE Skakkebaek, E Rajpert-De Meyts… - Physiological …, 2016 - journals.physiology.org
It is predicted that Japan and European Union will soon experience appreciable decreases
in their populations due to persistently low total fertility rates (TFR) below replacement level …

Molecular basis of human sperm capacitation

LC Puga Molina, GM Luque, PA Balestrini… - Frontiers in cell and …, 2018 - frontiersin.org
In the early 1950s, Austin and Chang independently described the changes that are
required for the sperm to fertilize oocytes in vivo. These changes were originally grouped …

Control of intracellular pH and bicarbonate by CO2 diffusion into human sperm

E Grahn, SV Kaufmann, M Askarova, M Ninov… - Nature …, 2023 - nature.com
The reaction of CO2 with H2O to form bicarbonate (HCO3−) and H+ controls sperm motility
and fertilization via HCO3−-stimulated cAMP synthesis. A complex network of signaling …

Sperm ion channels and transporters in male fertility and infertility

H Wang, LL McGoldrick, JJ Chung - Nature Reviews Urology, 2021 - nature.com
Mammalian sperm cells must respond to cues originating from along the female
reproductive tract and from the layers of the egg in order to complete their fertilization …

Molecular changes and signaling events occurring in spermatozoa during epididymal maturation

MG Gervasi, PE Visconti - Andrology, 2017 - Wiley Online Library
After leaving the testis, spermatozoa have not yet acquired the ability to move progressively
and are unable to fertilize oocytes. To become fertilization competent, they must go through …

Progesterone activates the principal Ca2+ channel of human sperm

PV Lishko, IL Botchkina, Y Kirichok - Nature, 2011 - nature.com
Steroid hormone progesterone released by cumulus cells surrounding the egg is a potent
stimulator of human spermatozoa. It attracts spermatozoa towards the egg and helps them …

[HTML][HTML] Human olfactory receptors: novel cellular functions outside of the nose

D Maßberg, H Hatt - Physiological reviews, 2018 - journals.physiology.org
Olfactory receptors (ORs) are not exclusively expressed in the olfactory sensory neurons;
they are also observed outside of the olfactory system in all other human tissues tested to …

Structure of a mammalian sperm cation channel complex

S Lin, M Ke, Y Zhang, Z Yan, J Wu - Nature, 2021 - nature.com
The cation channel of sperm (CatSper) is essential for sperm motility and fertility,. CatSper
comprises the pore-forming proteins CATSPER1–4 and multiple auxiliary subunits …

Calcium channels in the development, maturation, and function of spermatozoa

A Darszon, T Nishigaki, C Beltran… - Physiological …, 2011 - journals.physiology.org
A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …

Major regulatory mechanisms involved in sperm motility

R Pereira, R Sá, A Barros, M Sousa - Asian Journal of Andrology, 2017 - journals.lww.com
The genetic bases and molecular mechanisms involved in the assembly and function of the
flagellum components as well as in the regulation of the flagellar movement are not fully …