Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease refractory to all
targeted and immune therapies. However, our understanding of PDAC microenvironment …

The endoplasmic reticulum is an organelle exerting crucial functions in protein production,
metabolism homeostasis and cell signaling. Endoplasmic reticulum stress occurs when cells …

Selenoprotein K (SELK) is imperative for normal development of chicken. It does regulate to
chicken's physiological function. However, the injury of SELK-deficiency done on chicken …

Cancer is a leading cause of death worldwide. Casein kinase 2 (CK2) is commonly
dysregulated in cancer, impacting diverse molecular pathways. CK2 is a highly conserved …

Abstract Background Sec23 homolog A (SEC23A), a core component of coat protein
complex II (COPII), has been reported to be involved in several cancers. However, the role of …

In patients with sepsis, neutrophil apoptosis tends to be inversely proportional to the severity
of sepsis, but its mechanism is not yet clear. This study aimed to explore the mechanism of …

Chronic low-grade inflammation and neuronal deregulation are two components of a
smoldering disease activity that drives the progression of disability in people with multiple …

Tebuconazole (TEB) is a triazole fungicide used to increase crop production by controlling
fungi, insects, and weeds. Despite their extensive use, people are concerned about the …

Metastatic progression of epithelial cancers can be associated with epithelial-mesenchymal
transition (EMT) including transcriptional inhibition of E-cadherin (CDH1) expression …

Background Arginine deprivation therapy (ADT) hinders glioma cells' access to nutrients by
reducing peripheral blood arginine, showing great efficacy in various studies, which …