International union of basic and clinical pharmacology. xciv. adhesion g protein–coupled receptors

J Hamann, G Aust, D Araç, FB Engel… - Pharmacological …, 2015 - Elsevier
The Adhesion family forms a large branch of the pharmacologically important superfamily of
G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention …

Sticky signaling—adhesion class G protein–coupled receptors take the stage

T Langenhan, G Aust, J Hamann - Science signaling, 2013 - science.org
Adhesion-type heterotrimeric guanine nucleotide–binding protein (G protein)–coupled
receptors (Adhesion-GPCRs) comprise a class of widely distributed seven-transmembrane …

Molecular sensing of mechano-and ligand-dependent adhesion GPCR dissociation

N Scholz, AK Dahse, M Kemkemer, A Bormann… - Nature, 2023 - nature.com
Adhesion G-protein-coupled receptors (aGPCRs) bear notable similarity to Notch proteins, a
class of surface receptors poised for mechano-proteolytic activation,–, including an …

The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins

MF Bolliger, DC Martinelli… - Proceedings of the …, 2011 - National Acad Sciences
C1q-like genes (C1ql1–C1ql4) encode small, secreted proteins that are expressed in
differential patterns in the brain but whose receptors and functions remain unknown. BAI3 …

Stalk-dependent and stalk-independent signaling by the adhesion G protein-coupled receptors GPR56 (ADGRG1) and BAI1 (ADGRB1)

A Kishore, RH Purcell, Z Nassiri-Toosi… - Journal of Biological …, 2016 - ASBMB
The adhesion G protein-coupled receptors (aGPCRs) are a large yet poorly understood
family of seven-transmembrane proteins. A defining characteristic of the aGPCR family is the …

The GPS motif is a molecular switch for bimodal activities of adhesion class G protein-coupled receptors

S Prömel, M Frickenhaus, S Hughes, L Mestek… - Cell reports, 2012 - cell.com
Adhesion class G protein-coupled receptors (aGPCR) form the second largest group of
seven-transmembrane-spanning (7TM) receptors whose molecular layout and function differ …

Cell adhesion receptor GPR133 couples to Gs protein

J Bohnekamp, T Schöneberg - Journal of Biological Chemistry, 2011 - ASBMB
Adhesion G protein-coupled receptors (GPCR), with their very large and complex N termini,
are thought to participate in cell-cell and cell-matrix interactions and appear to be highly …

Piconewton forces mediate GAIN domain dissociation of the latrophilin-3 adhesion GPCR

BL Zhong, CE Lee, VT Vachharajani, MS Bauer… - Nano Letters, 2023 - ACS Publications
Latrophilins are adhesion G-protein coupled receptors (aGPCRs) that control excitatory
synapse formation. Most aGPCRs, including latrophilins, are autoproteolytically cleaved at …

The emerging role of adhesion GPCRs in cancer

AA Gad, N Balenga - ACS pharmacology & translational science, 2020 - ACS Publications
Aberrant expression, function, and mutation of G protein-coupled receptors (GPCRs) and
their signaling partners, G proteins, have been well documented in many forms of cancer …

Insulin receptor-related receptor as an extracellular alkali sensor

IE Deyev, F Sohet, KP Vassilenko, OV Serova… - Cell metabolism, 2011 - cell.com
The insulin receptor-related receptor (IRR), an orphan receptor tyrosine kinase of the insulin
receptor family, can be activated by alkaline media both in vitro and in vivo at pH> 7.9. The …