[HTML][HTML] Hibiscus-cisplatin combination treatment decreases liver toxicity in rats while increasing toxicity in lung cancer cells via oxidative stress-apoptosis pathway

AA Hamza, GH Heeba, SO Hassanin, HM Elwy… - Biomedicine & …, 2023 - Elsevier
Cisplatin (CIS) is a broad-spectrum anti-carcinogen that causes cytotoxic effects both in
normal and cancer cells. The purpose of this study was to test whether Hibiscus sabdariffa …

Beyond the lungs: exploring diverse applications of bromhexine and ambroxol

E Ahmadi, A Afrooghe, ZE Soltani, M Elahi, M Shayan… - Life Sciences, 2024 - Elsevier
The respiratory tract is commonly affected in multisystem disorders. Although many drugs
have been developed to target various components of these diseases, there is still a need …

A novel effect of Aprepitant: Protection for cisplatin-induced nephrotoxicity and hepatotoxicity

H Un, RA Ugan, D Kose, Y Bayir, E Cadirci… - European journal of …, 2020 - Elsevier
Cisplatin is widely used chemotherapeutic drug and have some serious side effects as
tissue toxicity and nausea and vomiting. Aprepitant is used in clinic as an anti-emetic drug …

The protective effect of protocatechuic acid on hepatotoxicity induced by cisplatin in mice

SA Habib, GM Suddek, MA Rahim, RS Abdelrahman - Life sciences, 2021 - Elsevier
Cisplatin is one of the most potent anti-cancer drugs used for the treatment of various solid
tumors, yet it has several side effects that may limit its clinical use. Hepatotoxicity is one of …

The Employment of Genera Vaccinium, Citrus, Olea, and Cynara Polyphenols for the Reduction of Selected Anti-Cancer Drug Side Effects

J Maiuolo, V Musolino, M Gliozzi, C Carresi… - Nutrients, 2022 - mdpi.com
Cancer is one of the most widespread diseases globally and one of the leading causes of
death. Known cancer treatments are chemotherapy, surgery, radiation therapy, targeted …

Ambroxol, a mucolytic agent, boosts HO‐1, suppresses NF‐κB, and decreases the susceptibility of the inflamed rat colon to apoptosis: A new treatment option for …

S Cavalu, H Sharaf, S Saber, ME Youssef… - The FASEB …, 2022 - Wiley Online Library
Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown etiology that
increases the risk of developing colorectal cancer and imposes a lifelong healthcare burden …

Ameliorative effect of desloratadine against cisplatin-induced renal and testicular toxicity in rats: Attention to TLR4/NLRP3 inflammasome signaling pathway

AA Shaaban, RA Zaghloul, HE Kafl, DH El-Kashef - Life sciences, 2023 - Elsevier
Cisplatin (CIS) is a potent anticancer drug that is used in the treatment of different types of
cancer. Owing to its serious side effects, its clinical use is considerably limited. Aims: This …

[HTML][HTML] Renoprotective effect of scutellarin on cisplatin-induced renal injury in mice: Impact on inflammation, apoptosis, and autophagy

CY Sun, J Nie, ZL Zheng, J Zhao, LM Wu, Y Zhu… - Biomedicine & …, 2019 - Elsevier
Cisplatin remains the standard first-line chemotherapeutic agent in the treatment of many
types of cancers, but its clinical application is hindered by its severe nephrotoxicity. Previous …

Protective effect of rutin and β-cyclodextrin against hepatotoxicity and nephrotoxicity induced by lambda-cyhalothrin in Wistar rats: biochemical, pathological indices …

WA Ali, WA Moselhy, MA Ibrahim, MM Amin, S Kamel… - Biomarkers, 2022 - Taylor & Francis
Background This study aimed to assess hepatotoxicity and nephrotoxicity of Lambda-
cyhalothrin (LCT) and the protective effect of rutin alone and in combination with β …

Combination of pomegranate extract and curcumin ameliorates thioacetamide-induced liver fibrosis in rats: impact on TGF-β/Smad3 and NF-κB signaling pathways

AMH Gowifel, MG Khalil, SA Nada… - Toxicology …, 2020 - Taylor & Francis
Protection against liver injury and its consequences is considered an essential issue to
minimize the number of annual deaths caused by liver diseases. The present study was …