More than half a century has passed since the introduction of the National Filariasis Control
Program; however, as of 2023, lymphatic filariasis (LF) still prevails globally, particularly in …

ABSTRACT A milestone in the field of recombinant binding molecules was achieved 30
years ago with the discovery of single-domain antibodies from which antigen-binding …

Amplified ATP imaging in inflammatory cells is highly desirable. However, the spatial
selectivity of current amplification methods is limited, that is, signal amplification is performed …

Neurophotonics was launched in 2014 coinciding with the launch of the BRAIN Initiative
focused on development of technologies for advancement of neuroscience. For the last …

Immune checkpoint inhibition has transformed the treatment landscape of advanced
melanoma and long-term survival of patients is now possible. However, at least half of the …

The use of cell cycle inhibitors has necessitated a better understanding of the cell cycle in
tumor biology to optimize the therapeutic approach. Cell cycle aberrations are common in …

Cancer represents a leading cause of death worldwide. Hence, a better understanding of
the molecular mechanisms causing and propelling the disease is of utmost importance …

Encoded by PTPN11, the Src-homology 2 domain-containing phosphatase 2 (SHP2)
integrates signals from various membrane-bound receptors such as receptor tyrosine …

Calcium acts as a signal and transmits information in all eukaryotes. Encoding machinery
consisting of calcium channels, stores, buffers, and pumps can generate a variety of calcium …

Intravital microscopy (IVM) has revolutionized our understanding of single-cell behavior in
complex tissues by enabling real-time observation of molecular and cellular processes in …