Melanocytes are melanin-producing cells found in skin, hair follicles, eyes, inner ear, bones,
heart and brain of humans. They arise from pluripotent neural crest cells and differentiate in …

Melanoma is an aggressive malignancy originating from pigment-producing melanocytes.
The development of targeted therapies (MAPK pathway inhibitors) and immunotherapies …

Considerable progress has been made in identifying signaling pathways that direct the
differentiation of human pluripotent stem cells (hPSCs) into specialized cell types, including …

The transcription factor Sox9 was first discovered in patients with campomelic dysplasia, a
haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 …

Craniofacial microsomia (CFM) is the second most common congenital facial anomaly, yet
its genetic etiology remains unknown. We perform whole-exome or genome sequencing of …

Background Advances in burn care during the recent past have included improvements in
fluid resuscitation, early wound excision, respiratory support and management of inhalation …

Current opinion holds that pigment cells, melanocytes, are derived from neural crest cells
produced at the dorsal neural tube and that migrate under the epidermis to populate all parts …

The molecular biology of metastatic potential in melanoma has been studied many times
previously and changes in the expression of many genes have been linked to metastatic …

Maintain stemness, commit to a specific lineage, differentiate, proliferate, or die. These are
essential decisions that every cell is constantly challenged to make in multi-cellular …

In this review, we outline the gene-regulatory interactions driving neural crest development
and compare these to a hypothetical network operating in the embryonic ectoderm of the …