Radiation therapy is one of the major tools of cancer treatment, and is widely used for a
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …

The hypoxic tumour is a chaotic landscape of struggle and adaption. Against the adversity of
oxygen starvation, hypoxic cancer cells initiate a reprogramming of transcriptional activities …

Here, we examined the multigenerational effect of microplastics (6-μm polystyrene beads;
with different environmentally relevant concentrations of 0.023 and 0.23 mg/L in seawater) …

Major depressive disorder (MDD) is a prevalent and serious mental disorder with high rates
of suicide and disability. However, the underlying pathogenesis of MDD is complicated and …

Hypoxia, as a pervasive feature in the microenvironment of solid tumors, plays a significant
role in cancer progression, metastasis, and ultimately clinical outcome. One key cellular …

Diatoms, accounting for 40% of the marine primary production and 20% of global carbon
dioxide fixation, are threatened by the ongoing ocean warming (OW). However, whether and …

Hypoxia is a hallmark of the tumour microenvironment with profound effects on tumour
biology, influencing cancer progression, the development of metastasis and patient …

Dementia is a syndrome associated with a wide range of clinical features including
progressive cognitive decline and patient inability to self-care. Due to rapidly increasing …

Hypoxia is a common feature of solid tumors that is closely associated with radiotherapy and
chemotherapy resistance, metastasis and tumors prognosis. Thus, it is important to assess …

Identifying biomarkers and signaling pathways are important for the management of prostate
cancer (CaP) radioresistance. In this study, we identified differential proteins and signaling …