Chronic diabetic wounds and their treatment with skin substitutes

J Holl, C Kowalewski, Z Zimek, P Fiedor, A Kaminski… - Cells, 2021 - mdpi.com
With the global prevalence of type 2 diabetes mellitus steeply rising, instances of chronic,
hard-healing, or non-healing diabetic wounds and ulcers are predicted to increase. The …

Viscoelasticity, like forces, plays a role in mechanotransduction

CT Mierke - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Viscoelasticity and its alteration in time and space has turned out to act as a key element in
fundamental biological processes in living systems, such as morphogenesis and motility …

Engineered dermis loaded with confining forces promotes full-thickness wound healing by enhancing vascularisation and epithelialisation

G Zhang, Z Zhang, G Cao, Q Jin, L Xu, J Li, Z Liu, C Xu… - Acta Biomaterialia, 2023 - Elsevier
Tissue-engineered skin is ideal for clinical wound repair. Restoration of skin tissue defects
using tissue-engineered skin remains a challenge owing to insufficient vascularisation. In …

Pro-angiogenic and osteogenic composite scaffolds of fibrin, alginate and calcium phosphate for bone tissue engineering

N Kohli, V Sharma, A Orera… - Journal of tissue …, 2021 - journals.sagepub.com
Due to the limitations of bone autografts, we aimed to develop new composite biomaterials
with pro-angiogenic and osteogenic properties to be used as scaffolds in bone tissue …

A universal classification system of skin substitutes inspired by factorial design

E Davison-Kotler, V Sharma, NV Kang… - … Engineering Part B …, 2018 - liebertpub.com
The complexity of the dermal layer of skin means that damage to this section can result in
permanent impairment of function. Partial or total dermal loss is a feature of deep burns and …

Chitosan-based films with cannabis oil as a base material for wound dressing application

D Chelminiak-Dudkiewicz… - Scientific Reports, 2022 - nature.com
This study focuses on obtaining and characterizing novel chitosan-based biomaterials
containing cannabis oil to potentially promote wound healing. The primary active substance …

Hydrocolloids of egg white and gelatin as a platform for hydrogel-based tissue engineering

KG Pele, H Amaveda, M Mora, C Marcuello, A Lostao… - Gels, 2023 - mdpi.com
Innovative materials are needed to produce scaffolds for various tissue engineering and
regenerative medicine (TERM) applications, including tissue models. Materials derived from …

Cellular and molecular interaction of human dermal fibroblasts with bacterial nanocellulose composite hydrogel for tissue regeneration

EY Xi Loh, MB Fauzi, MH Ng, PY Ng… - … applied materials & …, 2018 - ACS Publications
The evaluation of the interaction of cells with biomaterials is fundamental to establish the
suitability of the biomaterial for a specific application. In this study, the properties of bacterial …

Pre-screening the intrinsic angiogenic capacity of biomaterials in an optimised ex ovo chorioallantoic membrane model

N Kohli, P Sawadkar, S Ho, V Sharma… - Journal of tissue …, 2020 - journals.sagepub.com
Biomaterial development for clinical applications is currently on the rise. This necessitates
adequate in vitro testing, where the structure and composition of biomaterials must be …

Ex ovo chorioallantoic membrane assay as a model of bone formation by biomaterials

N Owji, N Kohli, OG Frost, P Sawadkar, M Snow… - ACS Macro …, 2024 - ACS Publications
Biomaterials play an increasingly critical role in bone tissue engineering. However,
achieving effective clinical translation requires a careful choice of biomimetic materials and …