The first published description of therapeutic applications of antisense oligonucleotide
(ASO) technology occurred in the late 1970s and was followed by the founding of …

As the primary cellular location for respiration and energy production, mitochondria serve in
a critical capacity to the cell. Yet, by virtue of this very function of respiration, mitochondria …

During transcription, the nascent RNA can invade the DNA template, forming extended RNA-
DNA duplexes (R-loops). Here we employ ChIP-seq in strains expressing or lacking RNase …

Lung cancer (LC) is a heterogeneous disease consisting mainly of two subtypes, non-small
cell lung cancer (NSCLC) and small cell lung cancer (SCLC), and remains the leading …

As regulators of bioenergetics in the cell and the primary source of endogenous reactive
oxygen species (ROS), dysfunctional mitochondria have been implicated for decades in the …

While the majority of DNA is enclosed within the nucleus, the mitochondria also contain their
own, separate DNA, the mitochondrial DNA (mtDNA). Mutations in mtDNA are associated …

Significance: Reactive oxygen species (ROS) are generated by exogenous and
environmental genotoxins, but also arise from mitochondria as byproducts of respiration in …

Chronic progressive external ophthalmoplegia (CPEO) is common in mitochondrial
disorders and is frequently associated with multiple mtDNA deletions. The onset is typically …

Faithful DNA replication is essential for genome stability. To ensure accurate replication,
numerous complex and redundant replication and repair mechanisms function in tandem …

Hepatitis B virus (HBV) remains a major human pathogen despite the development of both
antiviral drugs and a vaccine, in part because the current therapies do not suppress HBV …