The existence of an endogenous cannabinoid system was demonstrated conclusively with
the discovery of endogenous brain constituents capable of activating the cannabinoid …

After the discovery, in the early 1990s, of specific G‐protein‐coupled receptors for
marijuana's psychoactive principle Δ9‐tetrahydrocannabinol, the cannabinoid receptors …

Cannabinoid receptors are molecular targets for marijuana and hashish, the widespread
drugs of abuse. These receptors are expressed in areas of the central nervous system that …

Epidemiological studies have documented a reduced prevalence of Alzheimer's disease
among users of nonsteroidal anti-inflammatory drugs (NSAIDs),,,,. It has been proposed that …

Palmitoylethanolamide (PEA), the naturally occurring amide of palmitic acid and
ethanolamine, reduces pain and inflammation through an as-yet-uncharacterized …

The potent analgesic effects of cannabis-like drugs,,, and the presence of CB1-type
cannabinoid receptors in pain-processing areas of the brain and spinal cord, indicate that …

Oleylethanolamide (OEA) is a natural analogue of the endogenous cannabinoid
anandamide. Like anandamide, OEA is produced in cells in a stimulus-dependent manner …

We measured endogenous cannabinoid release in dorsal striatum of freely moving rats by
microdialysis and gas chromatography/mass spectrometry. Neural activity stimulated the …

The background knowledge leading to the isolation and identification of anandamide and 2-
arachidonoyl glycerol, the principal endocannabinoids is described. The structure–activity …

Anandamide was the first brain metabolite shown to act as a ligand of “central” CB1
cannabinoid receptors. Here we report that the endogenous cannabinoid potently and …