Hereditary hemochromatosis (HH) is one of the most common genetic disorders among
persons of northern European descent. There have been recent advances in the diagnosis …

In the late 1800s, hemochromatosis was considered an odd autoptic finding. More than a
century later, it was finally recognized as a hereditary, multi-organ disorder associated with a …

To more fully characterize the available evidence supporting the recommendations, the
AASLD Practice Guidelines Committee has adopted the classification used by the Grading …

For many years, hereditary hemochromatosis was regarded as a clinically and genetically
unique entity marked by a classic presentation consisting of diabetes, bronze skin …

Background Most persons who are homozygous for C282Y, the HFE allele most commonly
asssociated with hereditary hemochromatosis, have elevated levels of serum ferritin and …

Iron overload in humans is associated with a variety of genetic and acquired conditions. Of
these, HFE hemochromatosis (HFE-HC) is by far the most frequent and most well-defined …

Asian populations are under-represented in human genomics research. Here, we
characterize clinically significant genetic variation in 9051 genomes representing East …

The mechanism (s) determining the progression from fatty liver to steatohepatitis is currently
unknown. Our goal was to define the relative impact of iron overload, genetic mutations of …

The discovery of hepcidin in 2000 and the subsequent unprecedented explosion of research
and discoveries in the iron field have dramatically changed our understanding of human …

Purpose This 3-year, prospective, multicenter trial assessed the safety and efficacy of
deferasirox in low-or intermediate-1–risk myelodysplastic syndrome (MDS). Patients and …