Today's challenge for precision medicine involves the integration of the impact of molecular
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …

Middle age has historically been an understudied period of life compared to older age, when
cognitive and brain health decline are most pronounced, but the scope for intervention may …

Studies in shift workers and model organisms link circadian disruption to breast cancer.
However, molecular circadian rhythms in noncancerous and cancerous human breast …

Aging alters the amplitude and phase of centrally regulated circadian rhythms. Here we
evaluate whether peripheral circadian rhythmicity in the plasma lipidome is altered by aging …

Abundant epidemiological evidence links circadian rhythms to human health, from heart
disease to neurodegeneration. Accurate determination of an individual's circadian phase is …

Recent single-cell transcriptomes revealed spatiotemporal programmes of liver function on
the sublobular scale. However, how sexual dimorphism affected this space-time logic …

Circadian timekeeping mechanisms and cell cycle regulation share thematic biological
principles in responding to signals, repairing cellular damage, coordinating metabolism, and …

Chronic liver disease and cancer are global health challenges. The role of the circadian
clock as a regulator of liver physiology and disease is well established in rodents, however …

Energetic demand and nutrient supply fluctuate as a function of time-of-day, in alignment
with sleep-wake and fasting-feeding cycles. These daily rhythms are mirrored by 24-hour …

The circadian system, composed of a network of brain and peripheral 24-hour clocks and
oscillators, allows organisms to anticipate and synchronize to natural daily events. The day …