Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

Poor memory ability and small hippocampal volume measurements in magnetic resonance
images co-occur in neurological patients. Numerous studies have examined the relationship …

One of the major neuropathological findings in the brains of individuals with Alzheimer's
disease (AD) is a loss of synaptic contacts in both the neocortex and hippocampus. Here we …

Objective: To evaluate the total number of synapses in the stratum radiatum (str rad) of the
human hippocampal CA1 subfield in individuals with mild Alzheimer disease (mAD), mild …

Numerous studies have reported a smaller hippocampal volume in Alzheimer's disease
(AD) patients than in aging controls. However, in mild cognitive impairment (MCI), the results …

Mild cognitive impairment (MCI), particularly the amnestic subtype (aMCI), is considered as
a transitional stage between normal aging and a diagnosis of clinically probable Alzheimer's …

To examine the biological basis of subjective memory impairment (SMI), defined as the
feeling of memory worsening with normal memory performance, we measured the volume of …

The purpose of the present study was to examine the types of impairments in everyday
function that accompany mild cognitive impairment (MCI). Data for this study was collected …

Increasing evidence suggests that oxidative damage is associated with normal aging and
several neurodegenerative diseases. Mild cognitive impairment (MCI), the phase between …

Objective To determine whether magnetic resonance imaging (MRI) white matter
hyperintensities (WMH), whole-brain atrophy, and cardiovascular risk factors predict the …