Pharmaceutical aspects of salt and cocrystal forms of APIs and characterization challenges

PC Vioglio, MR Chierotti, R Gobetto - Advanced Drug Delivery Reviews, 2017 - Elsevier
In recent years many efforts have been devoted to the screening and the study of new solid-
state forms of old active pharmaceutical ingredients (APIs) with salification or co …

Towards medicinal mechanochemistry: evolution of milling from pharmaceutical solid form screening to the synthesis of active pharmaceutical ingredients (APIs)

D Tan, L Loots, T Friščić - Chemical Communications, 2016 - pubs.rsc.org
This overview highlights the emergent area of mechanochemical reactions for making active
pharmaceutical ingredients (APIs), and covers the latest advances in the recently …

Creating cocrystals: A review of pharmaceutical cocrystal preparation routes and applications

M Karimi-Jafari, L Padrela, GM Walker… - Crystal Growth & …, 2018 - ACS Publications
Originally discovered almost a century ago, cocrystals continue to gain interest in the
modern day due to their ability to modify the physical properties of solid-state materials …

Pharmaceutical cocrystals: along the path to improved medicines

NK Duggirala, ML Perry, Ö Almarsson… - Chemical …, 2016 - pubs.rsc.org
Cocrystals, a long known but understudied class of crystalline solids, have attracted interest
from crystal engineers and pharmaceutical scientists in the past decade and are now an …

Modeling polymorphic molecular crystals with electronic structure theory

GJO Beran - Chemical reviews, 2016 - ACS Publications
Interest in molecular crystals has grown thanks to their relevance to pharmaceuticals,
organic semiconductor materials, foods, and many other applications. Electronic structure …

Pharmaceutical cocrystals: An overview

N Qiao, M Li, W Schlindwein, N Malek, A Davies… - International journal of …, 2011 - Elsevier
Pharmaceutical cocrystals are emerging as a new class of solid drugs with improved
physicochemical properties, which has attracted increased interests from both industrial and …

Advances in terahertz time-domain spectroscopy of pharmaceutical solids: A review

P Bawuah, JA Zeitler - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
The rapid development of terahertz time-domain spectroscopy (THz-TDS) as a highly
versatile analytical tool for the characterisation of pharmaceutical materials has drawn …

Mechanochemistry for organic chemists: an update

D Tan, T Friščić - European Journal of Organic Chemistry, 2018 - Wiley Online Library
We provide a brief overview of recent advances in the use of mechanochemical techniques
for the synthesis of organic molecules and materials, highlighting selected examples of …

Highly nonlinear optical organic crystals for efficient terahertz wave generation, detection, and applications

SJ Kim, BJ Kang, U Puc, WT Kim… - Advanced Optical …, 2021 - Wiley Online Library
Organic π‐conjugated crystals with second‐order optical nonlinearity are considerably
attractive materials for diverse terahertz (THz) wave photonics. An overview of the research …

Pharmaceutical cocrystal drug products: an outlook on product development

R Shaikh, R Singh, GM Walker, DM Croker - Trends in pharmacological …, 2018 - cell.com
Active pharmaceutical ingredients (APIs) are most commonly formulated and delivered to
patients in the solid state. Recently, an alternative API solid-state form, namely the …