The serotonin brainstem hypothesis for the sudden infant death syndrome

HC Kinney, RL Haynes - Journal of Neuropathology & …, 2019 - academic.oup.com
The sudden infant death syndrome (SIDS) is the leading cause of postneonatal infant
mortality in the United States today, with an overall rate of 0.39/1000 live births. It is defined …

Dopaminergic neurons inhibit striatal output through non-canonical release of GABA

NX Tritsch, JB Ding, BL Sabatini - Nature, 2012 - nature.com
The substantia nigra pars compacta and ventral tegmental area contain the two largest
populations of dopamine-releasing neurons in the mammalian brain. These neurons extend …

GABAergic modulation of serotonergic neurons in the dorsal raphe nucleus

F Hernández-Vázquez, J Garduño… - Reviews in the …, 2019 - degruyter.com
The dorsal raphe nucleus (DRN), located in the brainstem, is involved in several functions
such as sleep, temperature regulation, stress responses, and anxiety behaviors. This …

Activation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2

R Bos, K Sadlaoud, P Boulenguez… - Proceedings of the …, 2013 - National Acad Sciences
In healthy adults, activation of γ-aminobutyric acid (GABA) A and glycine receptors inhibits
neurons as a result of low intracellular chloride concentration ([Cl–] i), which is maintained …

Late development of the GABAergic system in the human cerebral cortex and white matter

G Xu, KG Broadbelt, RL Haynes… - … of Neuropathology & …, 2011 - academic.oup.com
Despite the key role of γ-aminobutyric acid (GABA) neurons in the modulation of cerebral
cortical output, little is known about their development in the human cortex. We analyzed …

Morphological changes of glutamatergic synapses in animal models of Parkinson's disease

RM Villalba, A Mathai, Y Smith - Frontiers in neuroanatomy, 2015 - frontiersin.org
The striatum and the subthalamic nucleus (STN) are the main entry doors for extrinsic inputs
to reach the basal ganglia (BG) circuitry. The cerebral cortex, thalamus and brainstem are …

The serotonergic anatomy of the developing human medulla oblongata: implications for pediatric disorders of homeostasis

HC Kinney, KG Broadbelt, RL Haynes… - Journal of chemical …, 2011 - Elsevier
Abstract The caudal serotonergic (5-HT) system is a critical component of a medullary
“homeostatic network” that regulates protective responses to metabolic stressors such as …

[HTML][HTML] Role of the Dorsal Raphe Nucleus in Pain Processing

H Zhang, L Li, X Zhang, G Ru, W Zang - Brain Sciences, 2024 - mdpi.com
The dorsal raphe nucleus (DRN) has gained attention owing to its involvement in various
physiological functions, such as sleep–awake, feeding, and emotion, with its analgesic role …

Neuropathological features of unexplained sudden unexpected death in infancy: current evidence and controversies

SML Paine, TS Jacques… - … and applied neurobiology, 2014 - Wiley Online Library
Sudden infant death syndrome (SIDS) is a leading cause of postneonatal infant death in the
developed world. The cause of SIDS is unknown but several hypotheses have been …

Brainstem deficiency of the 14-3-3 regulator of serotonin synthesis: a proteomics analysis in the sudden infant death syndrome

KG Broadbelt, KD Rivera, DS Paterson… - Molecular & Cellular …, 2012 - ASBMB
Impaired brainstem responses to homeostatic challenges during sleep may result in the
sudden infant death syndrome (SIDS). Previously we reported a deficiency of serotonin (5 …