Neurotrophins use two types of receptors, the Trk tyrosine kinase receptors and the p75
neurotrophin receptor (p75NTR), to regulate the growth, development, survival and repair of …

Over a half a century of research has confirmed that neurotrophic factors promote the
survival and process outgrowth of isolated neurons in vitro. The mechanisms by which …

Neurotrophins protect neurons against glutamate excitotoxicity, but the signaling
mechanisms have not been fully elucidated. We studied the role of the phosphatidylinositol …

Transactive response DNA-binding (TDP-43) protein is the dominant disease protein in
amyotrophic lateral sclerosis (ALS) and a subgroup of frontotemporal lobar degeneration …

The serine/threonine kinase Akt, or protein kinase B (PKB), has recently been a focus of
intense research. It appears that Akt/PKB lies in the crossroads of multiple cellular signaling …

Neurotrophins activate several different intracellular signaling pathways that in some way
exert neuroprotective effects. In vitro studies of sympathetic and cerebellar granule neurons …

In contrast to injuries in the central nervous system, injured peripheral neurons will
regenerate their axons. However, axotomized motoneurons progressively lose their ability to …

Injury-induced downregulation of neurotrophin receptors may limit the response of neurons
to trophic factors, compromising their ability to survive. We tested this hypothesis in a model …

The time‐dependent decline in the ability of motoneurons to regenerate their axons after
axotomy is one of the principle contributing factors to poor functional recovery after …

Neuroblastoma is a common childhood tumor derived from the peripheral nervous system.
Favorable neuroblastomas usually express TrkA, the receptor for nerve growth factor (NGF) …