I. Executive Summary Background The 5 years since the publication of the first International
Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed …

In contrast to the major families of small molecules and antibodies, cyclic peptides, as a
family of synthesizable macromolecules, have distinct biochemical and therapeutic …

Aspergillosis refers to a spectrum of illness that is dependent on host factors and the
immunologic response. Noninvasive forms include allergic bronchopulmonary aspergillosis …

Although polyenes were the first broad spectrum antifungal drugs on the market, after 70
years they are still the gold standard to treat a variety of fungal infections. Polyenes such as …

It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

Chronic pulmonary aspergillosis (CPA) is an uncommon and problematic pulmonary
disease, complicating many other respiratory disorders, thought to affect∼ 240 000 people …

Background Isavuconazole is a novel triazole with broad-spectrum antifungal activity. The
SECURE trial assessed efficacy and safety of isavuconazole versus voriconazole in patients …

These guidelines are intended for use by infectious disease specialists, orthopedic
surgeons, neurosurgeons, radiologists, and other healthcare professionals who care for …

We have examined the effect of profound hypothermia on gut mucosal perfusion in 20
infants, aged 1.4-45 weeks, requiring cardiopulmonary bypass (CPB). After induction of …

The clinical presentation of Aspergillus lung disease is determined by the interaction
between fungus and host. Invasive aspergillosis develops in severely immunocompromised …