Insights on the use of α-lipoic acid for therapeutic purposes

B Salehi, Y Berkay Yılmaz, G Antika… - Biomolecules, 2019 - mdpi.com
α-lipoic acid (ALA, thioctic acid) is an organosulfur component produced from plants,
animals, and humans. It has various properties, among them great antioxidant potential and …

NRF2 as a therapeutic target in neurodegenerative diseases

MS Brandes, NE Gray - ASN neuro, 2020 - journals.sagepub.com
Increased reactive oxygen species production and oxidative stress have been implicated in
the pathogenesis of numerous neurodegenerative conditions including among others …

Emerging therapies to target CNS pathophysiology in multiple sclerosis

J Oh, A Bar-Or - Nature Reviews Neurology, 2022 - nature.com
The rapidly evolving therapeutic landscape of multiple sclerosis (MS) has contributed to
paradigm shifts in our understanding of the biological mechanisms that contribute to CNS …

[HTML][HTML] Influence of diet in multiple sclerosis: a systematic review

MJ Bagur, MA Murcia, AM Jiménez-Monreal, JA Tur… - Advances in …, 2017 - Elsevier
Nutrition is considered to be a possible factor in the pathogenesis of the neurological
disease multiple sclerosis (MS). Nutrition intervention studies suggest that diet may be …

Lipoic acid: its antioxidant and anti-inflammatory role and clinical applications

F Andrea Moura, K Queiroz de Andrade… - Current Topics in …, 2015 - ingentaconnect.com
Lipoic acid (LA) is an antioxidant able to produce its effects in aqueous or lipophilic
environments. Lipoate is the conjugate base of lipoic acid, and the most prevalent form of LA …

Natural molecules and neuroprotection: kynurenic acid, pantethine and α-lipoic acid

F Tóth, EK Cseh, L Vécsei - International journal of molecular sciences, 2021 - mdpi.com
The incidence of neurodegenerative diseases has increased greatly worldwide due to the
rise in life expectancy. In spite of notable development in the understanding of these …

Safety evaluation of α-lipoic acid supplementation: A systematic review and meta-analysis of randomized placebo-controlled clinical studies

F Fogacci, M Rizzo, C Krogager, C Kennedy… - Antioxidants, 2020 - mdpi.com
Alpha-lipoic acid (ALA) is a natural short-chain fatty acid that has attracted great attention in
recent years as an antioxidant molecule. However, some concerns have been recently …

Coenzyme Q10 as a treatment for fatigue and depression in multiple sclerosis patients: A double blind randomized clinical trial

M Sanoobar, P Dehghan, M Khalili, A Azimi… - Nutritional …, 2016 - Taylor & Francis
Objectives: Multiple sclerosis (MS) is the chronic inflammatory and demyelinating disorder of
central nervous system which is accompanied with disability and negative life style changes …

Mechanics insights of alpha-lipoic acid against cardiovascular diseases during COVID-19 infection

L Rochette, S Ghibu - International Journal of Molecular Sciences, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China, in late December
2019. Since then, COVID-19 has spread rapidly worldwide and was declared a global …

The effects of Ellagic acid supplementation on neurotrophic, inflammation, and oxidative stress factors, and indoleamine 2, 3-dioxygenase gene expression in multiple …

G Hajiluian, SJ Karegar, F Shidfar, N Aryaeian… - Phytomedicine, 2023 - Elsevier
Background Depression is one of the most common psychological disorders among multiple
sclerosis (MS) patients that characterized as the first symptoms. Ellagic acid is a natural …