Polarization, a primary step in the response of an individual eukaryotic cell to a spatial
stimulus, has attracted numerous theoretical treatments complementing experimental …

Chemotaxis in eukaryotic cells involves the coordination of several related but separable
processes: motility, polarization, and gradient sensing. Mathematical models that have been …

Motile eukaryotic cells polarize in response to external signals. Numerous mechanisms
have been suggested to account for this symmetry breaking and for the ensuing robust …

Directed cell migration by contact guidance in aligned collagenous extracellular matrix
(ECM) is a critical enabler of breast cancer dissemination. The mechanisms of this process …

Current models of eukaryotic chemotaxis propose that directional sensing causes localized
generation of new pseudopods. However, quantitative analysis of pseudopod generation …

Cell polarization is a key step in the migration, development, and organization of eukaryotic
cells, both at the single cell and multicellular level. Research on the mechanisms that give …

The mechanism of eukaryotic chemotaxis remains unclear despite intensive study. The most
frequently described mechanism acts through attractants causing actin polymerization, in …

Cell polarity is a general cellular process that can be seen in various cell types such as
migrating neutrophils and Dictyostelium cells. The Rho small GTP (guanosine 5′-tri …

Chemical reactions make cells work only if the participating chemicals are delivered to
desired locations in a timely and precise fashion. Most research to date has focused on …

To regulate shape changes, motility and chemotaxis in eukaryotic cells, signal transduction
pathways channel extracellular stimuli to the reorganization of the actin cytoskeleton. The …