Epigenetic silencing of immune-related genes is a striking feature of the cancer genome that
occurs in the process of tumorigenesis. This phenomena impacts antigen processing and …

Since its discovery in 1995, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL),
a member of the tumor necrosis factor super family, has been under intense focus because …

Vorinostat is a potent histone deacetylase inhibitor that blocks the catalytic site of these
enzymes. A large number of cellular proteins are modified post-translationally by acetylation …

Malignant melanoma is the most lethal type of skin cancer with high rates of mortality.
Although current treatment options provide a short-clinical benefit, acquired-drug resistance …

Numerous studies have investigated the potential use of TNF-related apoptosis-inducing
ligand (TRAIL) as a cancer therapeutic since its discovery in 1995-because TRAIL is a …

Pharmacologic inhibition of the cytotoxic T lymphocyte antigen 4 (CTLA4) and the
programmed death receptor-1 (PD1) has resulted in unprecedented durable responses in …

Single agent therapies are rarely successful in treating cancer, particularly at metastatic or
end stages, and survival rates with monotherapies alone are generally poor. The …

The global incidence of melanoma has dramatically increased during the recent decades,
yet the advancement of primary and adjuvant therapies has not kept a similar pace. The …

Skin cancers are often resistant to conventional chemotherapy. This study examined the anti-
skin cancer properties of crude ethanol extract of mangosteen pericarp (MPEE) on human …

Background The increased incidence of malignant melanoma in recent decades, along with
its high mortality rate and pronounced resistance to therapy pose an enormous challenge …