Mitochondrial-derived peptides in aging and age-related diseases

SJ Kim, B Miller, H Kumagai, AR Silverstein, M Flores… - Geroscience, 2021 - Springer
A decline in mitochondrial quality and activity has been associated with normal aging and
correlated with the development of a wide range of age-related diseases. Here, we review …

Myeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signaling

J Cheng, M Li, E Motta, D Barci, W Song, D Zhou… - Cell Reports …, 2024 - cell.com
The DNA damage response (DDR) and the blood-tumor barrier (BTB) restrict
chemotherapeutic success for primary brain tumors like glioblastomas (GBMs). Coherently …

Oxidative damage? Not a problem! The characterization of humanin-like mitochondrial peptide in anoxia tolerant freshwater turtles

S Wijenayake, KB Storey - The Protein Journal, 2021 - Springer
Mitochondria was long thought to be an “end function” organelle that regulated the
metabolic flux and apoptosis in the cell. However, with the discovery of the mitochondrial …

[HTML][HTML] Exogenous humanin and MOTS-c function as protective agents against gentamicin-induced hair cell damage

D Waldmann, Y Lu, M Cortada, D Bodmer… - Biochemical and …, 2023 - Elsevier
Loss of hair cells can lead to irreversible sensorineural hearing loss. Therefore, hair cell
preservation is critical for hearing. Mitochondrial derived peptides (MDPs) are bioactive …

Exploring the Role of Mitochondrial DNA Mutations in Cancer Development and Diagnosis

F Caldıran, MN Aydemir - 2024 - Springer
Cancer is an intricate web of diseases marked by the uncontrolled proliferation of abnormal
cells. At its core lies the complex interplay of genes, where inherited mutations or …