Six‐Membered Aromatic Nitrogen Heterocyclic Anti‐Tumor Agents: Synthesis and Applications

J Li, A Gu, XM Nong, S Zhai, ZY Yue… - The Chemical …, 2023 - Wiley Online Library
Cancer stands as a serious malady, posing substantial risks to human well‐being and
survival. This underscores the paramount necessity to explore and investigate novel …

[HTML][HTML] KIAA1429 promotes tumorigenesis and gefitinib resistance in lung adenocarcinoma by activating the JNK/MAPK pathway in an m6A-dependent manner

X Lin, R Ye, Z Li, B Zhang, Y Huang, J Du… - Drug Resistance …, 2023 - Elsevier
Non-small cell lung cancer is the leading cause of cancer related mortality worldwide, and
lung adenocarcinoma (LUAD) is one of the most common subtypes. The role of N6 …

[HTML][HTML] Drug delivery systems of gefitinib for improved cancer therapy: A review

D Nagdiya, M Kumar, S Arora, T Bajaj, S Kujur, P Rana… - OpenNano, 2023 - Elsevier
Lung cancer is an uncontrolled and abnormal mass of growing cells with the highest
mortality rate in the world. Progressive lung cancer shows a robust resistance to cancer …

Polyphyllin I ameliorates gefitinib resistance and inhibits the VEGF/VEGFR2/p38 pathway by targeting HIF-1a in lung adenocarcinoma

D Zhang, X Tian, Y Wang, F Liu, J Zhang, H Wang… - Phytomedicine, 2024 - Elsevier
Background Lung adenocarcinoma (LUAD) is the most common pathological type of lung
cancer. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have been …

Cytotoxic effect of crotoxin on cancer cells and its antitumoral effects correlated to tumor microenvironment: A review

TC Almeida, LMR Silva, AMB de Oliveira… - International Journal of …, 2023 - Elsevier
Cancer is the second leading cause of death worldwide, and despite the effort of standard
treatments, the search for new tools against this disease is necessary. Importantly, it is …

3D printing injectable microbeads using a composite liposomal ink for local treatment of peritoneal diseases

R Eugster, AA Ganguin, A Seidi, S Aleandri… - Drug delivery and …, 2023 - Springer
The peritoneal cavity offers an attractive administration route for challenging-to-treat
diseases, such as peritoneal carcinomatosis, post-surgical adhesions, and peritoneal …

Synthesis and Biological Evaluation of 2-Substituted Quinazolin-4(3H)-Ones with Antiproliferative Activities

M Karelou, D Kampasis, AD Kalampaliki, L Persoons… - Molecules, 2023 - mdpi.com
Sixteen new 2-substituted quinazolines were synthesized using a straightforward
methodology starting from 2-methoxybezoic acid or 3-methoxy-2-naphthoic acid. The anti …

Development of Erlotinib-Loaded Nanotransferosomal Gel for the Topical Treatment of Ductal Carcinoma in Situ

B Mangla, P Mittal, P Kumar, S Javed, W Ahsan… - …, 2024 - Taylor & Francis
Aims: This study was aimed to formulate erlotinib (ERL)-loaded transferosomal gel (ERL@
TG) intended for topical application for the treatment of ductal carcinoma in situ. Materials & …

Amelioration of the therapeutic potential of gefitinib against breast cancer using nanostructured lipid carriers

P Kumar, B Mangla, S Javed, W Ahsan… - Nanomedicine, 2023 - Taylor & Francis
Aim: This study aimed to improve the delivery and therapeutic potential of gefitinib (GTB)
against breast cancer by preparing GTB-loaded, nanostructured lipid carriers (GTB-NLCs) …

Establishment of a novel microfluidic co-culture system for simultaneous analysis of multiple indicators of gefitinib sensitivity in colorectal cancer cells

X Li, W Li, J Wang, Q Wang, M Liang, S Chen, W Ba… - Microchimica Acta, 2024 - Springer
The therapeutic effect of gefitinib on colorectal cancer (CRC) is unclear, but it has been
reported that stromal cells in the tumor microenvironment may have an impact on drug …