Flip-flop pharmacokinetics is a phenomenon often encountered with extravascularly
administered drugs. Occurrence of flip-flop spans preclinical to human studies. The purpose …

Infection preventive practice of using disinfectants against SARS-CoV-2 has become the
new normal due to the COVID-19 pandemic. Although disinfectants may not be applied …

A proposal has been developed by the Agricultural Chemical Safety Assessment (ACSA)
Technical Committee of the ILSI Health and Environmental Sciences Institute (HESI) for an …

Firefighters face significant risks of exposure to toxic chemicals, such as polycyclic aromatic
hydrocarbons (PAHs), during fire suppression activities. PAHs have been found in the air, on …

Ortho-phenylphenol (OPP) and its sodium (SOPP) and potassium (POPP) salts are used as
fungicides and disinfectants. Due to the widespread use of especially OPP and SOPP, the …

The validity of in vitro and in vivo methods for the prediction of percutaneous penetration in
humans was assessed using the fungicide ortho-phenylphenol (OPP)(log Po/w 3.28, MW …

Pesticide toxicology study design has evolved from concern for oral exposure via food
residues. The emphasis on the oral route does not generally apply to workers that are …

The accurate prediction of toxicokinetic parameters arising from oral, dermal and inhalation
routes of chemical exposure is a key element in chemical safety assessments. In this …

The biocides ortho-phenylphenol and its sodium salt (OPP and SOPP) are widely used as
fungicides and antibacterial agents for commercial and consumer purposes. The …

The controversy about the use of data from human volunteer studies involving experimental
exposure to pesticides as part of regulatory risk assessment has been widely discussed, but …