Low back pain (LBP), as a leading cause of disability, is a common musculoskeletal disorder
that results in major social and economic burdens. Recent research has identified …

Skeletal tissue is highly innervated. Although different types of nerves have been recently
identified in the bone, the crosstalk between bone and nerves remains unclear. In this …

The skeletal system is the third most common site for cancer metastases, surpassed only by
the lungs and liver. Many tumors, especially those of the breast, prostate, lungs, and …

Chronic low back pain (CLBP), lasting> 3 months, is the end result of multiple pathogenic
factors. Unfortunately, little is known about CLBP pathogenesis, which limits its …

Chronic pain is a major challenge to clinical practice and basic science. The peripheral and
central neural networks that mediate nociception show extensive plasticity in pathological …

A complex regional pain syndrome (CRPS)—multiple system dysfunction, severe and often
chronic pain, and disability—can be triggered by a minor injury, a fact that has fascinated …

Bone is richly innervated by nerve growth factor–responsive (NGF-responsive) tropomyosin
receptor kinase A–expressing (TrKa-expressing) sensory nerve fibers, which are required …

The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal
cells. Peripheral nerve endings release neurogenic factors and sense skeletal signals …

Introduction Peripheral neuropathies are a prevalent, heterogeneous group of diseases of
the peripheral nervous system. Symptoms are often debilitating, difficult to treat, and usually …

Chronic pelvic pain is a frustrating symptom for patients with endometriosis and is frequently
refractory to hormonal and surgical management. While these therapies target ectopic …