Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2).
IRPs bind to iron-responsive elements (IREs) located in the untranslated regions of mRNAs …

Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are mammalian proteins that register
cytosolic iron concentrations and post-transcriptionally regulate expression of iron …

With rare exceptions, virtually all studied organisms from Archaea to man are dependent on
iron for survival. Despite the ubiquitous distribution and abundance of iron in the biosphere …

▪ Abstract Complex II is the only membrane-bound component of the Krebs cycle and in
addition functions as a member of the electron transport chain in mitochondria and in many …

As an essential nutrient and a potential toxin, iron poses an exquisite regulatory problem in
biology and medicine. At the cellular level, the basic molecular framework for the regulation …

Advances in CRISPR technology have immensely improved our ability to manipulate nucleic
acids, and the recent discovery of the RNA-targeting endonuclease Cas13 adds even further …

RNA-binding proteins (RBPs) have roles in the regulation of many post-transcriptional steps
in gene expression, but relatively few RBPs have been systematically studied. We searched …

▪ Abstract Mammalian iron homeostasis is maintained through the concerted action of
sensory and regulatory networks that modulate the expression of proteins of iron metabolism …

Sixty years ago Carl Martius (1906-1993), then “Wissenschaftlicher Assistent” to Franz
Knoop at the Biochemical Institute of the University of Tubingen, did an experiment, crucial …

Cellular iron homeostasis is accomplished by the coordinated regulated expression of the
transferrin receptor and ferritin, which mediate iron uptake and storage, respectively. The …