BACKGROUND: Hypoxia may contribute to the pathogenesis of various diseases of the
vascular wall. Hypoxia-inducible factors (HIFs) are nuclear transcriptional factors that …

Despite the obvious clinical significance of post-stroke angiogenesis in aged subjects, a
detailed transcriptomic analysis of post-stroke angiogenesis has not yet been undertaken in …

Background Pulmonary fibrosis is a debilitating and lethal disease with no effective
treatment options. Understanding the pathological processes at play will direct the …

Abstract Purpose Arteriovenous fistulae (AVFs) created by conventional surgical techniques
are associated with suboptimal short-and long-term patency. This study investigated the …

An arteriovenous fistula (AVF) is the preferred vascular access for chronic hemodialysis, but
high failure rates restrict its use. Optimizing patients' perioperative status and the surgical …

Objective—Transdifferentiation of adventitial fibroblasts (AFs) into myofibroblasts plays a
critical role during the vascular remodeling that occurs during atherosclerosis, restenosis …

Venous neointimal hyperplasia (VNH) causes hemodialysis vascular access failure. Here
we tested whether VNH formation occurs in part due to local vessel hypoxia caused by …

Pulmonary arterial hypertension (PAH) is a progressive disease characterized by increased
pulmonary vascular resistance (PVR), causing right ventricular hypertrophy and ultimately …

Background Idiopathic pulmonary fibrosis (IPF) is an age-related, progressive and lethal
disease, whose pathogenesis is associated with fibroblasts/myofibroblasts foci that produce …

Abdominal aortic aneurysm (AAA) is potentially life-threatening in aging population due to
the risk of aortic rupture and a lack of optimal treatment. The roles of different vascular and …